一对一理科课题：研究成年小鼠星形胶质细胞在体外和原位降解淀粉样蛋白-β

课题内容

阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特点是淀粉样β（Aβ）肽在大脑中过度沉积。AD最早的神经病理变化之一是星形胶质细胞在Aβ沉积部位的堆积1，但这种细胞反应的原因或意义尚不清楚。这里我们显示，培养的成年小鼠星形胶质细胞在单核细胞诱导蛋白-1（MCP-1）的作用下迁移，这是一种存在于AD病变中的趋化因子1，并在与固定的Aβ1-42相互作用时停止迁移。

我们还表明，星形胶质细胞会结合并降解Aβ1-42。星形胶质细胞镀在来自AD小鼠模型的充满Aβ的大脑切片上，与Aβ沉积物结合，并降低这些切片中的整体Aβ水平。我们的结果表明，星形细胞在Aβ沉积物周围聚集的新机制，表明星形细胞在降解Aβ方面的直接作用，并将星形胶质细胞清除Aβ的缺陷与AD的发病机制联系起来。因此，增加星形细胞清除Aβ的治疗可能是减少与AD相关的神经变性的一个关键机制

教授介绍

哥伦比亚大学

终身教授

1.2008年至2012年期间获得美国国防部专项资金。

2.2007年获得文理职业发展Revel奖。

课程大纲-美国和全球公共卫生疾病控制方法及政策研究

COURSE TOPIC: Foundations of Public Health

The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be

adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1: Core Functions of Public Health

• Individual vs population health

• Ten essential services of public health

• Primary, secondary, tertiary prevention

• Introduction to determinants of health

• Social class, racism, discrimination and privilege in public health systems

Session 2: Healthcare Systems and Delivery in the US and Globally

• Approaches to healthcare

• Quality and coverage

• Implementation (e.g., cost, workforce)

• Regulatory systems

• Novel approaches to bridge healthcare and communities

• Social class, racism, discrimination and privilege in healthcare delivery

Session 3: Population Health: Past, Present and Future

• Trends in morbidity and mortality

• History of public health and impact of globalization

• Pragmatic challenges

• Diversity, equity, and inclusion

Session 4:Final

• Public health case:Take COVID-19 as an example

• Final project reveal

课程大纲-免疫系统原理机制及疾病抗体研究

COURSE TOPIC: Immunology and Vaccination

The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.

This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1 Introduction to immunology

Acquired immunity- characteristics

Antigen, Haptens and Adjuvants, Antibody

Types of immunity: nonspecificphysiological and cellular barriers

Session 2 Cells and Organs of Immune system

Organs of immune system – primary and secondary

Cells of immunsystem

Humoral Immuneresponse

Session 3 Immuno-techniques